How and why insect wings developed, however, is not well understood, largely due to the scarcity of appropriate fossils from the period of their development in the Lower Carboniferous.
The process of dominance is not well understood largely because it is not possible to trace the cellular changes that occur within a follicle in real time in order to relate the events preceding development to future outcomes, such as predicting whether an individual follicle will become dominant or subordinate.
Second, model selection in multiple regression involving both fixed and random factors is not well understood; it is still largely unknown how best to conduct model selection in mixed effects models (e.g., whether AICC, BIC or other information criteria are best suited).
However, the natural history of DCIS is not well understood, as it has largely been extrapolated from historical series and reassessment of previously misdiagnosed lesions, most of which were low grade.
While previous studies revealed that SRPK1 phosphorylates RS1, regiospecific and temporal-specific control within the largely redundant RS domain is not well understood.
Unfortunately, this photo-induced phenomenon called "photounbinding" has been largely ignored and its basic mechanism is not yet understood.
What is not widely understood outside of India is that these Christian schools are largely Hindu.
Biological onset of OA is not clearly understood but evidence suggests that progression of cartilage degradation is mediated largely by pro-inflammatory cytokines [ 31, 32].
However, while the mechanisms of protein degradation have been largely elucidated (Hirata et al., 2002), how mRNA stability is regulated is not well understood.
However, MECs are still largely unexplored and their reaction to pathological conditions as well as a potential role during disease is not well understood.
