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Interestingly, activated rhodopsin of the outer segment is not internalized in response to light [48], suggesting that in PCs, receptors might be sequestered from classical downregulation pathways involving clathrin-mediated endocytosis.
(C ) Jen1-KR-GFP is not internalized in response to glucose.
It should be noted that the Jen1-KR mutant couldn't be used to answer this question, because although it is expressed and targeted to the plasma membrane, it is not internalized in response to glucose due to its lack of ubiquitylation (see new Figure 2C).
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Summing up, although environmental costs are not internalized in a market transaction, waste treatment costs are internalized and paid by households instead of producers in a market equilibrium.
Although this interaction does not appear in a market equilibrium in which waste treatment charges are on households while environmental costs are not internalized in the production, it does appear in a specific type of equilibrium which is defined as a sustainable equilibrium in this paper.
In contrast, HSA coupled to the control mAb was not internalized in macrophages, or only in very low amounts in some cells.
Rm1 and Rm2 were not internalized in response to α-MSH during either a 2-h (Fig. 7B and C) or 4-h exposure (not shown).
This internalization was clearly mediated by Sn and not by other macrophage receptors, since isotype matched control mAbs were not internalized in the cell and since 41D3 fragmentsragments, lacking the Fc domain, are internalized similarly to intact 41D3.
However, the majority of EGFR was not internalized in cells transfected with Tom1L1 siRNA as only 20% of the biotinylated EGFR was protected from the surface stripping.
The mono-amphiphile (m-C11 G2) complexes showed no cellular uptake with no detectable signal from Cy3-siRNA, while bola-C18-G1/siRNA complexes formed aggregates on the cell surface and were not internalized, in agreement with the observed low gene knockdown for both of these vectors.
Furthermore, it is not known if the toxin is internalized before, during, or after the initial lysis or if it is not internalized.
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