Associations with one Asian-specific SNP that is not in linkage disequilibrium with the established SNP at that genomic region, rs9485372 (6q25.1, TAB2 c.6 + 68962G > A), was replicated in the COGS study above (Table 3) [ 37]; however, other SNP associations have not yet been replicated.
Since rs12901499 is not in linkage disequilibrium with a non-synonymous polymorphism, it is likely the association is operating by influencing expression of SMAD3.
RARB was reported to be the nearest gene, although the SNP is not in linkage disequilibrium with the coding region.
Thirdly, we assume that the UV is not in linkage disequilibrium with an unknown deleterious mutation.
In people of African descent, rs8099917 is not in linkage disequilibrium with rs12979860 and does not predict response.
As the rs4730751 tag SNP is not in linkage disequilibrium with other genetic variants located in exons that may truncate or otherwise alter CAV1 gene product, the causative variant is likely to be regulatory rather than coding.
According to a recent review (Abrahams and Geschwind 2008), one gene on 2p, NRXN1 (neurexin 1), has been implicated in clinical ASD but is located at 2p16, which is not in linkage disequilibrium with rs11894053.
Furthermore, haplotype analysis using the expectation-maximization algorithm showed that the rs1045642, rs1128503, and rs2032582 are in tight linkage disequilibrium with each other (D′ value of >0.7, Figure 1) but the rs3213619 is not in linkage disequilibrium with the former ones.
