Comparison of female yw dFatp het survival to revertant lines was inconclusive, however, as female revertants lived longer than yw controls (Fig. S3B), indicating that the survival phenotype of the insertion is not fully rescued by precise excision.
Although I potentially support the publication of the present research, my main concern is that the effect of the mutations on the three imprinted genes is not fully understood and thus their precise role in triploid block remains unknown.
Reviewer #1: Although I potentially support the publication of the present research, my main concern is that the effect of the mutations on the three imprinted genes is not fully understood and thus their precise role in triploid block remains unknown.
The precise etiology is not fully understood; one undisputed origin lies in the placenta.
Although the precise mechanism is not fully elucidated, key proton transfers are thought to be important in the RNAP bond addition reaction.
Although the precise mechanism is not fully understood, frameshifting occurs with a frequency of 5 10% in cultured HIV-transfected human cells, and the Gag to Gag-Pol ratio appears to be important for viral fitness.
This model has high specificity and flexibility in controlling the extent of pancreatic severity, which makes it suitable for studying extrapancreatic organ damage, but the precise mechanism is not fully understood.
However, the biological function of this binding is not fully understood, and to date, the precise molecular mechanisms by which G9a and, in particular its ANK domain, contribute to de novo DNA methylation remain unclear.
Its precise function is not fully elucidated, but Peterson et al. [ 8] have shown in a series of elegant experiments that knocking down DEPTOR leads to activation of signalling through mTORC1 and mTORC2.
Although its precise mechanism is not fully understood, some reports have mentioned that specific cell membrane-associated drug efflux transporters, such as multidrug resistance protein-1 (MRP-1) and breast cancer resistance protein (BCRP), are induced upon therapy with MTX [ 25, 26].
