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In other nations it is not difficult to identify cases which are of notable interest, that appear to have been able to overcome these difficulties.
Existing drugs only target a small fraction of essential growth pathways, and it is not difficult for Mycobacterium tuberculosis (Mtb) to overcome their inhibition by activating compensatory pathways.
An unrecognizable and universally ignored doodle at a checkout stand isn't difficult for thieves to overcome – leaving consumers vulnerable to common credit card fraud.
And even when there is a real awareness of things not being OK, it's difficult to overcome cultural barriers to disruption.
If these are not overcome, it's very difficult to overcome the other imbalances in the world such as the American trade deficits and imbalance between China and the rest of the world.
And all of these extraordinary things were done by ordinary people just like me... then it can't be that difficult to overcome the negatives, can it?
For a more realistic balance, Moore suggests having only "one indulgent thing" in your living space at a time and leaving the rest at the store (that midnight snack craving won't be as difficult to overcome if you've only got one option).
Even companies not accepting bailout money have canceled events, "because it is a perception thing and that is very difficult to overcome," she added.
Shutting two is extremely difficult to overcome.
But there's one obstacle that is still difficult to overcome.
We showed that the choice of the R-gene is of crucial importance: unlike Me3, that was rapidly overcome after successive re-inoculations in laboratory experiments or by natural field isolates, Me1 was either not or difficult to overcome under laboratory conditions or field conditions and only when it was weakened in a very susceptible genetic background.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com