The possibility of eradicating cancer by selective destruction of tumour blood vessels may represent an attractive therapeutic avenue, but most pharmaceutical agents investigated so far did not achieve complete cures and are not completely specific.
Since angiographic features in cerebral arteritis are not completely specific, the associated radiologic and clinical findings often are fundamental elements for a diagnosis [34].
Since pharmacological inhibitors are not completely specific, we performed a supplementary experiment using siRNA directed against Atg5, a protein involved in the lipidation of Atg8/LC3 [23] and hence in autophagosome formation.
Because it is now known that pharmacological inhibitors of autophagy are not completely specific to the autophagic process and thus may produce secondary or off-target effects [55], we finally included the use of RNAi technology for specific inhibition of autophagy.
Although pharmacological inhibitors (Table 3) can be used to inhibit internalization processes, these inhibitors are not completely specific and may suppress more than one cellular uptake pathway.
