Likewise, although some political scientists continue to insist that only quantified data are legitimate, some topics are not amenable to study in these terms.
These effects were not amenable to study by the methods reported herein, since we injected tumor cells directly into the bone and therefore could not investigate release and trafficking of tumor cells or seeding of tumor cells at secondary sites.
However, endpoint measurements obtained from methods that pool populations of cells are not amenable to studying time-dependent processes that show cell heterogeneity.
Neuronal tracer studies, while significantly more specific than tractography, are labor intensive, require an a priori hypothesis of the affected pathway, and are not amenable to studying multiple pathways within the same brain.
In part, we attribute this to a relatively high level of conserved organization in SAR11 genomes, and the role of hypervariable regions, which by definition are not amenable to studies based on the identification of conserved genome features.
A drawback of our study design is that we cannot explore the early phases of disease development, since SMA is not amenable to a prospective study design because the required close follow up to detect early hematological changes prevents the development of SMA [40].
Although the human cortex is not amenable to anatomical tracer studies, the emergence of noninvasive neuroimaging methods, including tractography using diffusion imaging and functional connectivity using resting-state fMRI, opens the possibility of learning much about the human connectome (Behrens and Sporns 2012; Van Essen and Ugurbil 2012; Van Essen et al. 2012).
Nevertheless, there can be situations in which laboratory genetics are more challenging or even impossible, for example when the identified polymorphism is in an essential gene, or when the species being studied is not amenable to genetic manipulation.
In circumstances in which the outcome assessors are not fully blinded, or in which the intervention is not amenable to rigorous blinding, placebo surgery studies are not ethical.
It is a membrane embedded protein that is not amenable to the methods used in our study.
This regulatory locus is not amenable to the analysis techniques utilized for this study, due to its repetitive nature and the fact that its chromosomal location is within the region excluded from this analysis by comparative genome hybridization results, so direct comparisons cannot be made.
