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Consistently, the G153E, L154D and 153 154 amino acid substitutions rendered cellular intoxication via ANTXR2, which is normally sensitive to inhibition by NH4Cl treatment, resistant to that treatment (Fig. 1C).
E. coli is normally sensitive to the antibiotic ampicillin unless a periplasmic β-lactamase (Bla) is expressed.
Because the IRS-1/PI-3 kinase pathway is defective, the MAP kinase pathway is excessively stimulated since it is normally sensitive to insulin.
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After removal of their cataracts, such newly sighted people are found to be normally sensitive to changes in intensity of illumination and to colour.
Like the animals given brain lesions, these mice are normally sensitive to heat and mechanical pain, but they do not avoid situations where they experience such pain.
The results indicate that exergy values and 2nd law efficiency are normally sensitive to reasonable variation in dd, L/G and H, but do not respond greatly to reasonable variation in vd, and va.
Thus, we tested the response of this system when P.aeruginosa was added in the presence of two antibiotics one at levels lower than the MIC (kanamycin, 50 µg/ml) and other much higher than they are normally sensitive to (gentamicin, 100 µg/ml) in rich medium.
Bad-deficient lymphocytes were normally sensitive to cytokine deprivation and to DNA damage, evoked either by etoposide or γ-irradiation.
The brain cells are normally sensitive to the effects of ROS because they are a nidus for peroxidisable molecules, and because of their peculiar energetic demands [ 4].
This analysis revealed that CD4+CD8+ thymocytes from both Bok −/− Bax −/− and Bok −/− Bak −/− double-knockout mice were normally sensitive to all treatments tested (Supplementary Figure 6).
We have previously generated BOK-deficient mice; like BAX or BAK singly deficient animals, Bok −/− mice developed normally and were healthy; moreover, their leukocytes were normally sensitive to diverse cytotoxic stimuli.
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