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The key issue concerns what is needed for knowledge and whether the general sort of evidence we have — something we can identify from our armchairs — meets the relevant necessary condition for knowledge.
The appendix on what Kant called Leibniz' Amphiboly contains the first explicit discussion of an important general metaphysical notion, numerical identity (being one object at and over time), and contains the first argument in CPR for the proposition that sensible input is needed for knowledge.
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Knowledge users were considered to be the connection to the health system that is needed for the knowledge produced through research to have an impact on health outcomes.
Establishment of centres of excellence in cardiac imaging is needed for dissemination of knowledge in cardiac imaging research.
Indeed, all philosophical knowledge is needed for good decision-making.
However, more knowledge is needed, for example, on the microstructural and matrix dissolution behaviour of ThO2.
Nursing knowledge is needed for designing, implementing, and updating software, including an electronic health record (EHR).
Hence more knowledge is needed, for example on ongoing changes in governance arrangements regarding municipal green space.
Conservation research aims to address the gap between what is known and what knowledge is needed for effective conservation.
Further knowledge is needed for prevention.
This knowledge is needed for valid interpretation of results of meta-analyses of diagnostic studies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com