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Given the absence of clinical markers to guide use, the pharmacokinetic data suggests that for mild hepatic impairment, no dose adjustment is necessary upon initiation, but patients with moderate impairment may need lower starting doses as a precaution.
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It was necessary upon arrival to seek out a pub to find the appropriate TV channel for the cricket and the first one, albeit on a bank holiday, shut at 6.30pm.
Restarting your PC may then be necessary upon completion of system registry clean up, hard drive defragmentation, and disk space clean out.
Investments in innovations and new technologies that may be necessary upon further energy price increases may be difficult or expensive to implement.
Reassessment of the diagnostic nature of this character may be necessary upon the discovery of new data, because no squamosal material is yet known for any taxa within Carcharodontosauria aside from Acrocanthosaurus atokensis.
Thus, further testing of our predictions will be necessary upon availability of better estimates for the crowding coefficients.
Photo identification will be necessary upon arrival at parks to verify pass ownership.
Using this formula is necessary, because upon re-annealing, one duplex of mutant DNA can produce two duplexes of mutant:wild-type hybrid, doubling the actual TE frequency.
Amid the various narratives of "the truth" now being rehearsed by the Russian state, it is necessary to insist upon a reality; on Friday morning Mr Nemtsov was alive, but by the day's end he was dead.
To reach the personal and moral attributes of God, it is necessary to draw upon further features of the world and argue a posteriori (D 38, W 2.543).
It is very likely that there is not one single solution to the problem but that it is necessary to call upon a whole set of means such as energy efficiency improvement, deployment of renewable energies, clean coal technologies including CO2 capture and storage, nuclear development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com