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A limited set of adaptation experiments indicate that the putative receptor is narrowly tuned.
The spatial weighting function is narrowly tuned to the preferred orientation, reflecting the highly significant anisotropies of long-range fibers in visual cortex [25].
Therefore, the auditory system of horseshoe bats is equipped with a filter mechanism that is narrowly tuned to each bat's individual RF.
But experimental data have shown that the gene product of frame-shifted, cloned hOR17– 210 cDNA was able to bind an odorant-binding protein and is narrowly tuned for excitation by cyclic ketones to perform chemosensory function.
Overall, hydration changes the aldehyde functional group to such an extent that, among those ORs that are specific for, that is, narrowly tuned to, the aldehyde functional group, it is unlikely that a single activated receptor conformation would recognize and be stabilized by both forms.
Similar(55)
Recent investigations have shown that PNs are broadly tuned to odors, whereas ORNs are narrowly tuned [3], [30].
The localization cues ITD and ILD are processed in parallel pathways in the brainstem [16] [18], where neurons are narrowly tuned to sound frequency (Reviews: [4], [5]).
A number of insect general odorant receptors also respond to very low odorant concentrations and a small proportion of them are narrowly tuned [46], [47].
In terrestrial vertebrates, it is suggested that chemosensory receptors expressed in MOE (ORs and TAARs) are broadly tuned generalists, whereas vomeronasal receptors (V1Rs and V2Rs) are narrowly tuned specialists.
Our experiments suggest that ORs with "broad" response spectra [44] may actually be narrowly tuned to cognate ligands yet to be discovered and underscore the necessity to test individual enantiomers when chiral odorants are involved.
Lu et al. [16] showed that AgOR8, when expressed in oocytes, was narrowly tuned and responded best to the racemic 1-octen-3-ol among a panel of 82 odorants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com