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It does not have to depend on being part of a 'socially progressive' company either – and it is in businesses that are not as forward thinking, where change is most required.
The makers of films like "Wedding Crashers" and "Hitch" seem determined to withdraw their comic fangs in the presence of romance, which is precisely when their bite is most required.
The decision of the majority in the House of Representatives to plunge ahead less than a month before the elections may be seen in future years as one that risks chaos when America's leadership is most required abroad.
The point has been made time and again: Too much fear can be as hazardous and costly as too little; sometimes what is most required is the courage and the wisdom to do less, not more.
We know funding has not always been applied where it is most required.
Exponentially growing cells divide rapidly and need to synthesize cell wall, hence MurA and MurG enzymes localize when cell wall synthesis is most required.
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Finally, and appropriately, the British driver looked a little embarrassed but he failed to display a champion's style when it was most required.
"What's most required for the part is a confidence to just say the words as written, plainly and forcefully, and not try to twist the words into sounding part of some deeply thought-out performance," Mr. Cromer said.
And all of a sudden, that location becomes a risk because critical services can't be reached during, say, inclement weather, which may be when they are most required.
Facing a side likely to stack up in defence and flood the midfield, it looked like just the sort of match when the guile and quality of Manchester United new boy Juan Mata would be most required.
Britain has not been given emphatic government just when that was most required.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com