In a second group, embracing members of the three studied enzymes, the ability to be modulated upon effector binding depends on the ratio between the kcat of the engineered enzyme and the kcat of the intact enzyme.
Our new data indicate that, in inflammatory settings, expression of JAM-3 may be modulated upon AnxA1 administration (pharmacological studies) or AnxA1 deficiency (patho-physiological investigations).
We recently showed that the miRNA expression profile of HBMVECs was modulated upon exposure of these brain endothelial cells to glioblastoma cells [11].
Indeed, very few genes of this family are modulated upon EGF stimulation, mostly in a down-regulation manner (Fig. 8D; see Table S2 for complete C3H10T1/2 array results, n/a for skin and somites explants).
Overall, these results provide evidence that both the host and viral miRNA regulation layers are modulated upon PRV infection of the PRV-DCs experimental system, and strongly suggest that their interplay is part of the process to establish latency.
We assessed whether expression of DNA methyl transferases (DNMT) was modulated upon Len/VD3 treatment.
The expression of these genes was modulated upon exposure to culture conditions favoring cell differentiation.
To identify the transcripts that were modulated upon infection, we compared the three libraries that were constructed.
Recently, the activity of ion channels coupled to GPCR was modulated upon ligand binding, demonstrating that GPCR are suitable binding domains for biosensors [ 28].
For example, proinflammatory pathways are known to be involved in the pathophysiology of PPCM [ 8, 23], which appear to be modulated upon treatment with bromocriptine [ 9, 23].
