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This is why the CFTR potentiator drug, VX-770 (ivacaftor, Kalydeco) [ 54] is markedly effective in G551D-CFTR patients, while the CF corrector drug, VX-809, corrects/rescues ΔF-CFTR from ER quality control and is without effect on G551D-CFTR patients [ 55, 56].
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This study suggested that nimodipine could be markedly effective to reduce edema and hematoma volume when administered in combination with other neuroprotective agents because ICH can induce brain injury by multiple mechanisms.
It was confirmed from the experimental results that the proposed MIP-carousel process was markedly effective in separating Cu2+ from Mn2+ and Co2+ in a continuous mode with high purity and a relatively small loss.
All the synthesized compounds proved to be markedly effective against human tumour cells: A549, HeLa, T47D and TOV112D and more cytotoxic than pemetrexed against A549, HeLa and T47D cells.
The diet was markedly effective for 3 patients (33%) and effective for 3 patients (33%).
In this study, the combined treatment was markedly effective in vivo, but not in vitro.
Thus, administration of either compound within 1 hour after disease induction was markedly effective across a representative range of local and systemic biochemical, immunologic, and histologic disease responses.
In the long term, while PVD alone slowly improves the anatomical results, it is markedly less effective than additional ILM removal.
Meta-analyses clearly demonstrate that CBT significantly reduces GAD symptoms and is markedly more effective than placebo or wait-list control conditions for GAD (Level 1) [ 55, 64, 65, 70, 520].
However, initial animal data were generated using the subcutaneous administration of a poorly soluble form of endostatin that is likely to have acted as a depot (O'Reilly et al, 1997) and subsequent work has shown that continuous infusion of endostatin is markedly more effective than bolus administration in animal models (Kisker et al, 2001).
The structure of a school is markedly less significant than an effective head teacher, a faculty which embraces change, and quality professional development.
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