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The results of 3D-QSAR models indicates that inhibition potency of steroidal AIs is markedly dependent on the hydrophobic nature of steroid core and potent steroidal AIs form hydrogen bonds with residues and interact with the heme iron.
The results of molecular modeling calculations suggest that the orientation of the bound inhibitor in the substrate binding cleft is markedly dependent on the stereochemistry of the epoxysuccinyl group.
The observed selectivity and potency (IC50 values 10 200 nM against HDAC6) is markedly dependent on the absolute configuration of the chiral moiety, and suggests new possibilities for use of chiral compounds in selective HDAC isoform inhibition.
The primary screening over a series of Ru and Ni-based catalysts shows that methanation activity is markedly dependent on the type of metal, the metal loadings and the promoter.
The phenotype of retinal alterations is markedly dependent on the developmental exposure period.
The nature of surface scanning behavior is markedly dependent on cell status.
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The cycling efficiency was markedly dependent not only on the co-solvent but also the Li salt.
The changes in the chemical characteristics and composition of the ablated area were found to be markedly dependent on the repetition rate.
The anodically generated radicals are trapped inefficiently (3 20%) but the proportions of α, β, and γ-isomers are markedly dependent on the medium.
The stereochemistry and the nature of the complexes are markedly dependent upon the molar ratios of the reactants, the pH of the system and the nature of the anions involved.
On comparing total GOD activities, as illustrated in Fig. 3b, although the overall trends were similar under different initial glucose concentrations, as they ascended rapidly to maximum values and then gradually descended until the end of fermentation, their increased degrees were markedly dependent on the initial conditions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com