Calculations of the initial velocity for each substrate concentration were made by fitting a linear equation to the data of the increase in L-kynurenine concentration during 1 min, and data were analysed using the Michaelis Menten equation (SigmaPlot, Systat Software).
The 95% confidence intervals of the measurements from patient 2 were made by fitting a Kimura distribution [Wonnapinij et al., 2008] to the 35 mutation level measurements from this patient, and then drawing 10,000 simulated sets of 35 measurements from this Kimura distribution to estimate the confidence intervals due to sample size effects [Wonnapinij et al., 2010].
The prediction is made by combining this distribution, fitted to the data, with population mortality tables.
The porous material in question is fitted glass, which is made by sintering together glass particles to form a porous solid.
The hardware, which can only be fitted to an iPhone, is made by BI2 Technologies of Plymouth, Massachusetts.
Adjustment for covariates was made by firstly fitting a standard logistic regression model to the individual-level data, including terms for the covariates of interest, but excluding the intervention effect.
To illustrate a higher order interrelationship among parameters, estimations were made by separately fitting the model to 3 individual data sets to plot the relations of the parameters in G4 p28, p29, p30), as shown in Figure 5.
Choice of statistical distribution can be made by independently fitting the different models to the data by maximum likelihood, and selecting the distribution that achieves the best fit (e.g. the lowest Akaike's Information Criteria or Bayesian Information Criterion) [ 5].
The model was fitted to mesothelioma mortality for Great Britain up to 2001 and projections of mortality were made by applying fitted mesothelioma rates to future population projections.
