In THAL, multiple astrocytic markers were lost consistent with glial cell loss.
As was seen with Pax2, by E12.5 mesenchymal expression of GDNF is completely lost, consistent with the hypothesis that the ureteric bud has not invaded the metanephric mesenchyme (Fig. 4k and l).
Although these studies did not explicitly address whether VDJ recombination is lost, phenotypes consistent with such loss were observed.
Therefore, the finding in human proband 1 that the dorsal raphe was lost is consistent with the possibility of long-term failure of normal feedback mechanisms.
Female Blimp1-null epiSCs also exhibited nuclear H3K27me3 foci, which is lost upon reversion to rESCs, consistent with the reactivation of the inactive X chromosome that occurs as efficiently in the absence of Blimp1.
For all samples, the bulk of LD is lost within 100-150 bps, which is consistent with previous observations (i.e., Huang et al. 2014).
Although 8.5% of Cited2 heterozygous pups are lost by weaning, consistent with the numbers of cardiac malformations observed, no deviation from expected numbers was seen during development.
None of the Tg-DrURE2 primary embryos (n = 0/4) had expression in these structures, suggesting that MmURE2 and CmURE2 share some enhancer activity that has been lost by DrURE2 consistent with absence of dlx1a/dlx2a expression in dorsal root ganglia.
This is consistent with synteny being lost with evolutionary time between members of the class Dothideomycetes [ 33].
Following irradiation, progressively more of the pattern was lost over 7 days, consistent with expression in both stem cell and immediate postmitotic progeny populations, and also consistent with previous irradiation data for mex3-1 (Solana et al., 2012).
