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As the transferrin receptor is located correctly at the plasma membrane in TS-mutant cells at 42°C, impaired endocytosis is a direct consequence of the temperature-sensitive effect of the mutant clathrin.
In the current build, 29, it is located correctly (see additional data file 1, blau_map.pdf).
However, the utility of this method is limited, because often it does not confirm conclusively whether the mutation is located correctly within the YAC.
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As much as 81% of the predicted high-propensity patch residues were located correctly in the native interfaces.
The valve positions were located correctly and operational settings were verified to obtain more realistic values of pipe roughness coefficients.
Using OPTWEI, the short-event nonstationary processes in Figures 7(c) and 7(f) are located correctly in the time interval as well as at the appropriate frequency.
Further, [16, 17, 18] proposed the concept of energy flow in the network, based on which the oscillation sources could be located correctly on a generator or a load bus.
As we move toward the fourth paradigm [4], where large aggregations of data are the key to discovery, it is imperative that the context of the data are articulated completely (or as completely as possible), not only to identify it's origin and authenticity, but more importantly to allow the data to be located correctly on the "scientific data map".
Lesions deemed to be suspicious for cancer (PI-RADS score 4 and 5) had a positive predictive value of 83% (25/30), and were located correctly in 88%.
The signal peptide of SDHD is composed of 56 amino acids, which provides the signal for SDHD to be located correctly in the inner membranes of mitochondria.
But when the correctly matching DNA is located, Cas9 undergoes a large structural change that releases this inhibition and triggers DNA cutting," said first author Samuel Sternberg, who recently received his Ph.D. at UC Berkeley.
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