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The second, mainly involved in the control of rae-1δ gene expression, is localized upstream of exon 4 and induces transcripts using a start site upstream of exon 3b.
SNP rs35753505 (SNP8NRG221533) is localized upstream of all transcript isoforms (RefSeq) of neuregulin 1, as shown in Fig. 3.
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Surprisingly, in M1, ACME was localized upstream of SCCmec and not downstream of SCCmec as in MRSA USA300 [4].
In some cases morpheme overlaps are localized upstream or near TSS of specific genes.
One of these potential promoters was localized upstream of the yebE rho-independent terminator (Fig. 1b, c).
The additional SNPs that were localized upstream of the region used for the original SNP panel are indicated by red lines in Fig. 1.
We detected several potentially conserved regions, of which most are localized upstream of the predicted pre-miRNA and one highly conserved region includes the pre-miR1432.
Finally, only the predicted promoters that are localized upstream of the phage structural and DNA packaging genes - which are organized in "+" cluster - have the extra "TATA" element.
In addition, transcriptional starts within mca and pup fragments and the respective sequence motifs resembling SigA-dependent promoters were localized upstream of these genes by primer extension (data not shown).
Finally, the source of the instability is localized in the upstream region, providing some clues to better understand and control the onset of the carbuncle.
This model argues that the c-Abl-p53 complex is localized downstream to Atm but upstream to p21 in the DNA damage signaling pathway that leads to G1 arrest.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com