We demonstrate that truncated unprocessed amino-terminal protein causes embryonic mispatterning, even when expression is localized to cells that normally express Hh, thus suggesting a role for autoprocessing in spatial regulation of hh signaling.
The polarity protein PAR3 associates with dynein to maintain a central position of the centrosome at the cell center [29], and in wound-edge fibroblasts this PAR3 is localized to cell-cell contacts and not the leading edge.
Antibody staining within the lamina propria is localized to cells within blood vessels and detrusor shows no evidence for NTPD3.
Except for pSmad2L with cytoplasmic localization (20, 21, 36), the other phosphoisoforms are localized to cell nuclei [ Figure 1C (24, 25, 25, 35, 38, 46– 51)].
Most strikingly, all conditions showed up-regulation of genes matching data from Mili, et al., a study that characterized RNAs that were localized to cell protrusions under chemotaxis and haptotaxis48.
Additionally, the extracellular matrix protein, fibronectin, was localized to cell banded areas by binding the protein to the cell surface prior to USWF exposure.
Ras GTPases are considered cytoplasmic proteins that must be localized to cell membranes for activation, and there are few evidences of the presence of any Ras isoform in nuclei of eukaryotic cells.
Y4 receptor-ir was localized to cell bodies of GCL, and proximal and distal INL.
Both the wildtype and R1838C proteins are localized to cell junctions (Fig. 5D,E).
