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In both cell types, actin-CB signal is localized primarily at sites of the plasma membrane.
Sirt3 is localized primarily at mitochondria and deacetylates cyclophilin D, a key component of the mPTP, thereby inhibiting mPTP opening.
In light of more recent work showing that NEP is localized primarily at the plasma membrane [ 43], it may be that extracellular NEP activity can influence intracellular Aβ levels to a certain degree, perhaps during the process of internalization of extracellular Aβ.
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This stability and the high positional reproducibility across experiments suggest that many H2A.Z nucleosomes are localized primarily at tall and locally unique maxima of histone-DNA affinity [2].
The same group showed that the NMDA receptor NR2A subunits are localized primarily at synapses and promote cell survival whereas NR2B subunits are contained predominantly in extra-synaptic NMDA-Rs and promote cell death.
EGF-bound EGFR was localized primarily at the plasma membrane at the zero time point.
STIM and Orai proteins, which are sensitive to and can be directly activated by low doses of 2-APB, are localized primarily at the sperm neck.
Depth-resolved recording indicated that the bright spots were localized primarily at z = 16-30 μm, relative to the PRL side retinal surface.
E-cadherin was localized primarily at cell-cell junctions of untreated cultures of wildtype and Smad3 null cells, although this feature was less clear in the Smad2 null cells.
In agreement with our previous findings, the Tam-R cell line was found to express erbB3 at high levels, whereas only minimal expression of erbB4 was observed in this cell line [ 32]. erbB3 expression was localized primarily at the cell membrane, although some cytoplasmic staining for this receptor was also observed by immunocytochemistry.
In mammalians, as in plants, EHD2 is localized primarily to the plasma membrane.
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