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NTS expression is also found in endocrine tumors and is linked to tissue differentiation [9].
For an example, in case of tuberculous meningitis, increased MMP-9 expression is linked to tissue destruction, a pathological hallmark of inflammatory host immune response [4] [5].
Any alteration in this balance is linked to tissue damage.
Further, it is known that Hmox-1 expression is linked to tissue stretch.
Normal physiology suggests that cardiac output is linked to tissue metabolic requirement.
In humans, HCC almost invariably develops in the context of chronic liver inflammation that is linked to tissue injury and cell death caused by viral hepatitis, chronic alcohol consumption, excessive hepatosteatosis or environmental toxins.
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The significance of these studies is that concentrations of plasma uric acid can be related to measures of oxidative stress, which can be linked to tissue aging.
Integrins are linked to tissue invasion by hepatocarcinoma cells [9] and play a role in apoptosis [10].
Angiogenic growth factors have recently been linked to tissue metabolism.
Recently, MRS lipids were linked to tissue hypoxia in tumours (Zoula et al, 2003).
The reemergence of these genes appears to be linked to tissue repair, but when an imprecise interaction of developmental and inflammatory signals occurs, complete healing is not achieved.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com