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Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G. & Jentsch, S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
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A proteomic analysis revealed that habituation to DCB is linked to modifications in several metabolic pathways.
However, mechanisms inducing such changes are underinvestigated and, probably, may be linked to modifications of the cell surface and/or interactions with the membrane.
However, CgA also shows ultradian variation, which does not appear to be linked to modifications of catecholamine release [ 36, 37].
Thus, the improvements in cardiovascular function that these investigators found may be linked to modifications of vascular or inflammatory biomarkers.
Gangliosides strongly control cell surface dynamics and signaling; therefore, it could be assumed that these alterations are linked to modifications of cell behavior acquired by the tumor.
In summary, the kinetics of placental and foetal growth altered by ART may be linked to modifications in various biological pathways, probably triggering the placental compensation phenomenon.
We then analyzed whether the observed changes in IGFBP-3 expression and promoter methylation were linked to modifications affecting the activation of the IGFIR/AKT cellular pathway, which could explain the observed differential sensitivity to ionizing radiation.
The function of Aurora kinase B is linked to chromatin modification in relation to phosphorylation of histone H3 at Ser10 [ 23].
This ruled out the possibility that the difference in glucose uptake is linked to a modification in the expression of these genes.
Some authors suggest that chronic FCF treatment is linked to a modification in Na,K-ATPase activity through the cyclic AMP-dependent protein kinase, nitric oxide synthase (NOS) activity, and cyclic GMP levels in the nucleus accumbens (NAc) and striatum (ST) [ 28].
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