To test these predictions requires a class of organisms evolving over geological timescales, with mass extinctions, and whose geometry is well-defined and can be linked to function.
Of the identified proteins that were linked to functions, the most commonly occurring functional categories were metabolic processes (133) and translation (110).
Twenty-two concepts were linked to functions related to the digestive system (b510 to b535).
Several genes, including Lef1, Lck, Crtam and Itk, have previously been linked to functions of the adaptive immune system.
The A. thaliana Epsin1 (ENTHA1 in our analysis) and EpsinR2/Epsin2 (ENTHA2) proteins, were linked to functions in the Golgi to vacuole pathway [ 33, 34].
Although these proteins have been linked to functions including apoptosis and pH and cell cycle regulation [ 11– 13], their exact role in normal cell physiology is uncertain.
The presence of central reflexes are indicators of consciousness that are linked to functioning of the brain stem or spinal cord.
The dynamic nature of microtubules has been linked to functions associated with cancer progression, including cell cycle progression and motility/invasion.
Many of the differentially expressed genes are linked to functions and pathways which appear to be relevant for the induction and maintenance of metastatic progression and may represent new therapeutic targets.
These findings provide further evidence that functional disconnection in distributed networks is linked to executive function in ASD.
