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Recombination is linked to efficacy of purifying selection in populations [ 38] and also within genomes.
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Although lithium's low therapeutic index had the potential to elicit untoward effects during a 4-month survival study, we sought to duplicate exactly the dosing regimen used by Fornai et al. [1] because it showed unequivocal efficacy, and this efficacy was linked to efficacy in ALS patients.
Table 3 summarizes known genetic polymorphisms that are linked to efficacy and adverse reactions of drugs commonly used in LN.
We also agree with the authors that toxicity could be linked to efficacy; however, this has not been shown in early drug development (Postel-Vinay et al, 2009).
In addition, it has been suggested that the development of hypertension is linked to treatment efficacy.
Because KRAS mutation status is linked to cetuximab/panitumumab efficacy, subpopulation dynamics could lead to differences in response to cetuximab/panitumumab in primary versus metastatic tumors.
DOTATOC-PET allows the radionuclide uptake to be evaluated, which is linked to radiopeptide therapy efficacy.
The biomedical interest in interferons is linked to their therapeutic efficacy against viral infections and cancer [ 11].
It is thus possible that the prognostic significance of the HER-2 status is linked to the therapeutic efficacy of trastuzumab-based treatments in this population.
The aim of this study was to evaluate whether and how the TP53 mutational status is linked to the varying efficacy of 5FU treatment in stage III colon cancer.
It possesses dipeptidylpeptidase IV (DPP IV) catalytic activity, which is linked to its co-stimulatory efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com