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Translational regulation of TGF-β1 mRNA is linked to altered binding of YB-1 protein to its 5'UTR.
Moreover, the GLIS3 locus is linked to altered fasting glucose level in healthy children and adolescents (Barker et al, 2011).
To determine if decreased dilp transcription in heads of esgGAL4>ndi1 flies is linked to altered sNPF/sNPFR1 expression, we measured transcript levels of sNPF and sNPFR1 in heads.
Overstimulation of the hypothalamic-pituitary-adrenal axis is linked to altered glucose and fat metabolism and development of overweight, obesity and insulin resistance (35), i.e., a Cushing's syndrome-like phenotype.
The GSTP1 polymorphism, resulting from an isoleucine to valine substitution within the active site of the enzyme at codon 105 (IV), is linked to altered substrate-specific thermostability and conjugation activity [ 10- 12].
Finally, as hyperactivity of the RAAS is linked to altered cardiovascular regulation our findings contribute to explain the increased risk for cardiovascular diseases observed in affective disorders [ 60, 61].
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Finally, reduction of TCR signal transmission by Nef was linked to altered actin remodeling and Lck IS recruitment but did not require endosomal Lck rerouting.
Most intriguing was the alteration in phosphatidylcholines, which can be linked to altered VLDL formation, which is a key factor in the pathogenesis of fatty liver disease.
Several genetic disorders and complex diseases have been linked to altered nuclear architecture and function.
Objective: Epidemiologic data suggest that the malignant transformation of ovarian epithelium may be linked to altered steroid hormone homeostasis.
NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients.
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