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Then, we determined whether down-regulation of CerS1 transcription is linked to alteration of endogenous Sp1 recruitment to the promoter in UM-SCC-1 cells compared to keratinocytes using quantitative-chromatin immuno-precipitation (Q-ChIP).
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Reference: Jaremka, Lisa M., et al. "Attachment anxiety is linked to alterations in cortisol production and cellular immunity".
Metabolic syndrome is linked to chronic inflammation - another major risk factor for the development of ischemic events, since inflammation is linked to alterations in coagulation [ 6, 8].
In terms of biological explanations, several laboratory studies have demonstrated how sleep restriction is linked to alterations in the production of hormones that control appetite, such as leptin and ghrelin, which may lead to subsequent weight gain [ 32, 33].
Breast cancer, which is a loss of tissue homeostasis, is characterized by perturbations in mammary tissue architecture, that is linked to alterations in the extracellular matrix (ECM) and in the adhesion molecules expressed by the MECs [ 1].
Therefore, further understanding of the underlying mechanisms in this model will help to develop treatments that counteract the adverse cardiac remodeling that is linked to alterations of SRF function in individuals with DCM.
A progressive reduction in renal function is linked to alterations in thyroid hormone levels and/or metabolism, resulting in high prevalence of subclinical hypothyroidism and the low T3 syndrome [ 31].
Ground based timber harvesting on wet sites has been linked to alteration of soil properties that may result in reduced long term site productivity.
The decrease in NEP expression has been linked to alteration in Aβ clearance leading to Aβ accumulation, which is considered to be an important event contributing to the development and progression of AD [7].
These effects appear to be linked to alteration of the AKT-signaling pathway.
The activity exerted by PgD5 against the phytopathogenic fungi and S. cerevisiae was linked to alteration of fungal membrane permeability.
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