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While introduction of a third phosphate maintains potent agonist activity, the pyrophosphate region of cADPR is demonstrably sensitive to conservative modifications: a methylenebisphosphonate substitution is less active and sulphur or selenium-substituted pyrophosphates demonstrate contrasting activities between diastereoisomers in ether-substituted analogues.
The new non-Peanut hamster is less active and smellier and develops a jutting, tusk-like tooth.
These have included the solar minimum – when the sun is less active and generating slightly less heat, as occurred in 2008/2009 – and a series of small volcanic eruptions, including that of Iceland's Eyjafjallajökull volcano in 2010.
At one pole, known as the animal pole, the cytoplasm appears to be more active and contains the nucleus (meiotic divisions occur in this region); at the other, called the vegetal pole, the cytoplasm is less active and contains most of the yolk.
The Pd/α-Si3N4 catalyst obtained by aqueous impregnation is less active and less stable.
Consistently, in the presence of FBP, PKM2R399E is less active and has less of a tendency to form a tetramer compared to PKM2WT (Fig. 1C and 1E).
Similar(46)
Although this may lead to less intensive physical activity than a structured activity intervention, this is designed to appeal to all students and especially those who may be less active and may not normally take part in physical activity promotion.
During environmental enrichment, it is likely that the pattern of ongoing synaptic activity would shift, such that some previously strengthened synapses would be less active and undergo less reinforcement of their synaptic weights.
UK pension funds and insurance companies are less active and expected to remain so in the runup to the referendum.
And far too many youngsters today are less active and less fit than their counterparts of previous generations.
Certain cellular enzymes may be less active, and thus more time may be required to carry out chemical reactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com