To show that the results obtained in neocortex were not due to differences in tissue handling, storage time, or quality, DNA methylation markers were also evaluated in cerebellum, a brain region that is largely spared from AD pathology.
Inactivation of ACCO is largely spared in the presence of bicarbonate and/or cyanide (Ververidis and Dilley 1995).
In summary, we find that long-distance and intermodular connectivity is largely spared from the ongoing streamline losses during development, which is potentially beneficial for the observed stability of small-world and modular connectome features.
We focused on hippocampal neurons because VAC14 expression in the hippocampus is similar to other brain regions (Supplementary Figure S1C) and the hippocampus is largely spared from neurodegeneration, even at the time of death in Vac14 −/− and Fig4 −/− animals (Chow et al, 2007; Zhang et al, 2007).
Previous studies of neonatal H-I in mice have shown that the cortex is largely spared from H-I injury in C57Bl6 mice (Gibson et al., 2001; Han et al., 2001; Hagberg et al., 2004; West et al., 2006; Zhu et al., 2006).
DOI: http://dx.doi.org/10.7554/eLife.07892.019 Taken together, the results of Figures 3 6 suggest that while the forward motion of individual paws is largely spared, ataxic pcd mice have specific deficits in coordinating movement in three dimensions across joints, limbs, and body.
