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A potential candidate for a transmembrane protein partner of the 500-kDa complex is the low-density lipoprotein (LDL) receptor related protein (LRP1), which is a large scavenger receptor mediating endocytosis of various biological components and is largely implicated in cytoskeleton organization [ 7, 62, 63].
The plasminogen activation system is largely implicated in pathological angiogenic processes.
MMP-2 is largely implicated in promoting angiogenesis and tumor metastasis.
Previous studies have shown that WNK1 is a negative regulator of cell growth via phosphorylation by the PI3-K/Akt signaling pathway [36], which is largely implicated in the schizophrenia pathophysiology.
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Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders.
But, in a study released earlier this year, a gene-hormone interaction that appears to be largely implicated was identified.
Gap junctions have also been shown to be largely implicated in the mediators- and endothelium-related relaxation [5], [30].
Local factors are largely implicated in inducing mammary involution [ 8– 10].
Histidine kinases (HK) are largely implicated in environment sensing and stress responses in fungi [ 41].
MMPs are largely implicated in promoting angiogenesis and tumor metastasis [ 16, 17].
These twelve genes were largely implicated in colonization (e.g. binding fibronectin, bone sialoproteins) and immuno-modulation (e.g. IgG binding, clumping factor A) [ 30, 32, 40, 46].
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