Neither is it known whether clinically significant immunosuppression is a common phenomenon, or only occurring in the most advanced patients, thus rarely indicating a need for immune-restoring therapy.
When the burden is so significant, whether it's because of new requirements around reporting quality measures, that type of thing can really drive out small practices, where they just can't compete, there's so much regulation.
From a food security viewpoint, it may be significant whether the increase in food availability per capita is provided by domestic production or imports.
In the current study, the ratio of positive nodes was significant whether it was entered as a continuous variable in multivariate analysis, dichotomized at the mean of 23.2%, or subgrouped based on ⩽10%, 10 50%, or >50% involvement.
It is a significant question whether groundwater models built to answer questions about water levels and flow rates can be used to explain possible causes of water-quality trends.
But that word, "wanted", emblazoned in red letters above a black-and-white image of his former friend's face, his eyes cast down and his lips forming a kind of plangent sneer, was powerfully significant, whether Freud allowed it or not.
Determine whether the arrangement of text on the page is significant, whether the order of lines and words is replaceable.
Although the Facebook investment represents a negligible percentage of Goldman's roughly $900 billion balance sheet, it is symbolically significant because it had been unclear whether the firm would, after the financial crisis, be using its balance sheet to make these types of illiquid, risky investments.
The availability of the home porch is significant whether a conversational exchange takes place or not.
Here it is crucial, whether significant improvements in HRQoL can be achieved in the situation of relatively expensive therapy.
