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MED12 is also a critical coactivator for the gene SOX9, which is involved in the developmental regulation of neurons, cartilage and bone.
HOXA5 is involved in the developmental regulation of the lung.
We suggest that S18-2 involvedved in the developmental regulation.
These results suggest the action of a gene that is involved in the developmental processes before birth, and which continues to have an effect on the adult.
The lethal phenotypes of both Mdm2 and Mdm4 knockout mice can be completely rescued by p53 null mice, demonstrating that p53 is involved in the developmental lethality of Mdm2 and Mdm4 knockout mice.
Claudin-1 (CLDN1) is involved in the developmental regulation of the tight junctions in mouse testis [ 30], while casein kinase 2, alpha prime polypeptide (CSNK2A2) null male mice are infertile and their cells from spermatogonia to early spermatids suffer nuclear envelope protrusions, outer membrane swelling and inner membrane disruption [ 31].
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Although some of the genes that showed significant changes in expression may also be involved in the developmental stage, there is no doubt that most of the responsive genes were expressed due to Pi stress as shown by the statistical confirmation of the differences in gene expression over time during −P and ++P treatments.
Soo was involved in the developmental process of the musical, according to Aaron Harnick, a producer of the show.
These two genes together with br, are major components of the transcription hierarchy that are involved in the developmental response to ecdysone by regulating the transcription of a large set of secondary ecdysone-response genes (for review see [50]).
The gradual demethylation of CpGs around the Stat3 recognition sequence in the GFAP promoter is thought to be involved in the developmental stage-dependent increase in transcription of the GFAP gene and the acquisition of astrocytic differentiation potentials [24], [25], [26].
The expression of BDNF, a member of the neurotrophin family of trophic factors that are involved in the developmental regulation of cell survival and differentiation and in the mediation of synaptic plasticity [100], [101], was also affected differentially by the METH challenge in the absence and presence of METH preconditioning.
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