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The core DNA binding domain is invariably present in all known p53-like transcription factors and its sequence similarity ranges from 37% to 42% within the starlet sea anemone p53-like protein family (Fig. 2A, B).
Our analysis of binding sites of ESC specific factors, chromatin remodelers, and structural chromatin organizers revealed that, regardless of H3.3 equilibrium levels, H3.3 dissociation is invariably high at protein factor binding sites and drops sharply where these factors are absent.
It is counted between 0 and 360° following the convention of the polar coordinates, so that the top of the cell has Φ = 90° and the bottom, where the contact with the TCR-binding surface is invariably initiated in our experimental setup, has the coordinate Φ = 270°.
Our data reveal that the CpG residue at the 5' end of the CTCF binding motif Y is invariably methylated.
Maintenance is invariably slapdash.
It is invariably fatal.
Eight-tenths is invariably fatal.
Incomprehension is invariably comical.
The sky is invariably freshly painted.
The building's lobby is, invariably, empty.
The pattern is invariably the same.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com