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Although it is well-established that E2F1 activity is intimately controlled through association with pRb, the precise mechanisms of this regulation are somewhat contradictory.
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The comparison between the FTIR and the XRD data, evidenced that these mechanisms are intimately controlled by the type of nanostructures that are formed depending on the clay content.
We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs.
Our in vivo perturbation of Dbf4 levels reproduces this consequence and points to other system observations: Cdc6 levels are intimately controlled by CDK levels to avoid re-replication, however this mechanism is tightly regulated such that Clb5 levels rising too soon would prevent the assembly of the pre-RC in G1, a feature of the system well documented.
Note that we did, however, find an enhanced gamma-band response (after grating onset) in right frontal cortex, a brain structure that is intimately involved in control of attention [ 33] although it did not correlate with the performance speeding here.
Active nutation control is intimately connected with gyroscopic stability and energy dissipation.
The striatum is intimately involved in motor control.
Thus, MLR, which is intimately linked to translation control, and the activity of mRNA-binding proteins like Puf3p, may provide the conditions for a fine spatiotemporal control of mitochondrial protein import and mitochondrial protein complex assembly.
Precise regulation of the subcellular distribution of class IIa HDACs is intimately linked to the control of their activity and plays a pivotal role in cellular processes and organ development [39].
Although there is strong evidence suggesting that tight glycemic control is intimately linked to an improved outcome in the intensive care unit (5), hyperglycemia in hospitalized patients is generally not considered a major therapeutic focus.
Since this contrasts with the situation in renal epithelia where SGK1 is intimately involved in the control of α-ENaC transcription [ 14, 38], further experiments explored the effects of pharmacological inhibitors of PI3K, since such compounds characteristically cause a profound loss of SGK1 activity (see e.g. [ 18, 22, 23]).
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