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Mab 123C3 is internalised into tumour cells, whereas both other anti-NCAM Mabs are not.
SW III-123 is internalised into cells via sigma-2 receptor-mediated endocytosis.
Previously, we have shown that a sigma-2 fluorescent probe, SW120, which is an analogue of SW 43, is internalised into cells through endocytotic mechanisms and distributed in mitochondria, endoplasm reticulum and lysosome (Zeng et al, 2011).
BTX-A injected into a muscle binds irreversibly to the nerve, where it is internalised into the nerve ending, causing paralysis of the muscle by preventing the release of acetylcholine.
ToxA is internalised into plant mesophyll cells subsequent to the pathogen penetrating the leaf [ 11] and interacts with the chloroplast-localized protein ToxA-BP1 leading to collapse of photosynthesis, the accumulation of reactive oxygen species (ROS) and eventually to cell death [ 12, 13].
After recognition at the cell surface, the particle is internalised into the cell and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, a multi-subunit enzyme, is assembled to produce the radical superoxide within the phagosome to digest the engulfed pathogen [ 7- 9].
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An antibody internalisation experiment showed RAET1G protein at the cell surface where it could be internalised into endosomes (Figure 6B).
It is the sole mechanism by which sugar phosphates are internalised into the staphylococcal cell.
Thus, WGA might be internalised into chondrocytes together with hyaluronan via the CD44 receptor-mediated endocytosis pathway and accumulated within lysosomes.
In this way, once the particles were internalised into the cancer cells, it was possible to obtain and analyse a tumour image in vivo.
In the first step, activated receptors are removed from cell membrane and are internalised into endosomes.
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