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IL-1β initiates and enhances inflammatory responses, hence, the production of bioactive IL-1β is normally tightly regulated at multiple levels: IL-1β is initially produced as an inactive precursor molecule that undergoes cleavage to produce bioactive IL-1β.
A set of BCs of base classifiers is initially produced with imbalanced reference data in the PROC space, where each BC curve corresponds to different level of imbalance (a growing number of non-target samples versus a fixed number of target ones).
TNF is initially produced as a 26 kDa transmembrane molecule (tmTNF), later to be cleaved by TNF-α Converting Enzyme (TACE) to release the soluble 17 kDa TNF cytokine (solTNF) [20].
Human lamin A is initially produced with a CaaX box (designated pre-lamin A) that is modified and subsequently cleaved to produce mature lamin A lacking a CaaX box [3].
For neurotrophic proteins such as GDNF, it is initially produced in vivo as an immature precursor that is processed proteolytically by furin-type endopeptidases, to liberate the mature functional protein from the propeptide [50].
In this type of diseases, a protein (e.g. amyloid precursor) is initially produced as a non lethal monomer which after triggering, oligomerizes, destroys cells and induces the onset of the disease [2].
Similar(47)
LG is initially producing two expansion packs but isn't revealing how much they will cost.
Though Achebe himself has been silent on the issue, Naijan, a Nigerian news website, reports that a spokesman for Achebe's Foundation, which manages his works, informed producers that "the novel with the said title was initially produced in 1958 (that is 17 years before rapper 50 Cent was born), listed as the mostly read book in modern African literature, and won't be sold for even $1bn".
"The novel with the said title was initially produced in 1958 (that is 17 years before [50] was born)," replied his lawyers, according to Naijan.
"Through the Night" was initially produced at the Riverside Theater in May and has reopened for an Off Broadway run at the Union Square Theater.
The films were initially produced using a standard RF sputtering technique.
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