The BA3443 enhancin was actually required for colonization of the worm gut (and soil) here, while the immune inhibitor A homologs BA0672 and BA1295 were individually required only for soil.
In addition, both the Hts and Isd systems are individually required for full virulence in systemic models of staphylococcal infection [2] [4] however their combined contribution to pathogenesis has not yet been elucidated.
A specific therapy for nephropathia epidemica is not generally applicable, but a symptomatic therapy including hemodialysis may be individually required.
Importantly, although we can quantify these individual contributions, it is clear in many contexts in cancer that hyperproliferation and inhibition of apoptosis are highly cooperative (Hanahan and Weinberg, 2011), and our data do not preclude the possibility that one or both are individually required.
We conclude that each of the genes tested is not individually required for starvation-induced quiescence in adult germ cells; likewise, quiescence is not affected by exogenous serotonin.
Interestingly, a doubling of the concentration of growth factors required for organoid culture (EGF, Noggin and R-spondin) enhanced the amplitude of PER2 rhythms (perhaps by increasing organoid size and number); however, these growth factors were not individually required for maintenance of PER2 rhythms once oscillations were established.
We demonstrated that both SPI-1 and SPI-2 contribute to cross-presentation, but are not individually required.
Bim−/−, Puma−/−, Bad−/− and Noxa−/− MEFs all died at rates similar to wild type controls, suggesting that these proteins are not individually required for NO-induced cell death (Figure 4B E).
Furthermore, Aop and Foxo are each individually required downstream of chico mutation for lifespan extension.
A stand-alone solar-powered device, such as a solar lantern, rechargeable lamp, or dedicated cell phone charger, is individually cheaper, more portable, does not require skilled installation, and, being self-contained, is less likely to require repair.
