As the adenylate cyclase enzyme encoded by the cya gene catalyzes formation of cAMP, which is indispensable for the function of CRP, we also constructed a cya deficient mutant and analyzed the level of Hcp.
These findings suggest that RXRα is indispensable for the function of PPARα, FXR, LXR and PXR in the mouse liver.
In particular, the expression of p66Shc is indispensable for the function of the p53 isoform (p44/p53) to induce of G2/M cell cycle arrest, after oxidative stress.
In addition, HDAC5 deficiency attenuated the repressive roles of IL-6 treatment and 5(g)), suggesting that HDAC5 is indispensable for the function of Stat3 to down-regulate PTPN13.
G protein γ-subunits are isoprenylated and carboxyl methylated at the C-terminal cysteine residue, and the set of the posttranslational modifications is indispensable for the function of the photoreceptor G protein transducin (Tα/Tβγ).
In addition, TKTL1 is indispensable for the function of the p53-dependent effector TIGAR (Tp53-induced glycolysis and apoptosis regulator) on hypoxia-induced cell death [ 10], and its expression correlates with HIF-1α expression and is induced upon hypoxic conditions which facilitate energy supply to tumors under these circumstances [ 10].
The mitochondrial genetic information is indispensable for the function of respiratory complexes I, III, IV, and V, as exemplified by the large number of human disorders attributed to mtDNA mutations and the role such mutations may play in aging (Trifunovic et al., 2004; Wallace, 1997).
Recently in Nature, Weinberg et al. (2019) reported that mitochondrial complex III is indispensable for suppressive function of regulatory T cells, thus highlighting the importance of mitochondria in immune tolerance.
Cadherin, a Ca2+-dependent glycoprotein with a single transmembrane domain, is indispensable for AJ function.
The accessory domain is indispensable for its function where it participates in dimerization of MABP-1 and in erythromycin binding.
