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Thus, it remains a major task to confirm that APC is indeed regulated by miR-142 in BCSCs and determine the level of regulation in this context.
Given this functional similarity as well as recent zebrafish transgenesis assays showing that the miR-9 family is indeed regulated by HCNEs with enhancer activity, we hypothesized that this type of miRNA regulation is prevalent.
Importantly, these studies on wild type embryos show that Mad phosphorylation by GSK3 is indeed regulated in vivo.
Three of the five identified posttranslational modifications are in fact disulfides, strongly suggesting that Glo1 is indeed regulated in response to the redox state of the cell.
ArgK is indeed regulated in crustaceans and mollusks under hypoxia [ 53, 54].
This is a remarkable correlation and suggests that CD44 is indeed regulated by DNA methylation in lymphoma cells.
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Therefore it is highly likely that many genes that are not in the RegulonDB target set are indeed regulated by Lrp.
Preliminary analyses of partial knockout of this gene indicate that at least some of these co-transcribed genes are indeed regulated by NF-Y (Lifang Feng and WM, unpublished observations).
To determine whether candidate targets with evolutionarily conserved Ap2-binding sites were indeed regulated by Ap2δ and Ash2l, we investigated the expression level of these targets upon downregulation of Ap2δ or Ash2l.
To verify whether VPAC1 protein expression was indeed regulated by miR-525-5p miR-525-5p miR-525-5pal setting, U937 cell line, in which miR525-5p was not expressed but into which hsa-more525-5physiologicalntly transetting, were harvested at different times and analysed for VPAC1.
Whether Tgl3 and Tgl5 activities are indeed regulated during the cell cycle is not known.
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