Because external validity of randomized controlled trials (RCTs) may be insufficient, the performance of nonrandomized controlled trials (nRCTs) is increasingly debated.
The Williams sisters and Biles aside, the wider question of whether widespread TUE usage is appropriate is one that is increasingly debated within anti-doping and sports science circles.
But, as the worth of these degrees is increasingly debated and the total U.S student loan nears a record breaking $1 trillion dollars, we have started to question that traditional approach to education.
The potential contribution of mechanical forces in the T cell activation process is increasingly debated, although these forces are scarcely defined and hold only limited experimental evidence.
Stenting in intracranial atherosclerotic disease (ICAD) is increasingly debated, due to issues of procedural safety, technical efficacy, and in-stent recurrent stenoses (ISR).
How to organise health research systems so as to maximise the benefits is increasingly debated at the national and international level, with some highly innovative developments resulting.
Furthermore, on-going treatment with metformin has been considered as a contraindication for intravenous contrast exposure (e.g., during emergent PCI) because of a perceived risk of lactic acidosis, although this contention is increasingly debated [ 17, 18].
However, it is increasingly debated whether such absolute distinctions between diagnoses exist; comorbidity is the rule rather than the exception, individuals often cross diagnostic boundaries over time, and there are 'boundary disputes' about how to classify presentations that fall between categories (Mineka, Watson, & Clark, 1998; Widiger & Samuel, 2005).
