However, it is increasingly clear that compound-induced interactions with multiple cardiac ion channels may significantly affect QT prolongation that would result from inhibition of only IKr [Redfern, W.S., Carlsson, L., et al., 2003.
The discovery of novel bioactive compounds is increasingly gaining importance.
Therefore, finding new molecular scaffolds with therapeutic benefit, and elucidating the biosynthetic pathways necessary to construct such compounds, is increasingly important.
In other words, our access to electricity and to clean water is increasingly tenuous in an era of compounded vulnerability due to climate change.
The existence of mechanisms leading to a dose response that is non-linear and has a practical threshold is increasingly recognized, not only for compounds that interact with non-DNA targets but also for DNA-reactive compounds [10].
Glycine betaine (betaine) is a naturally occurring compound which is increasingly being used in animal nutrition.
Oxaliplatin is a platinum compound that is increasingly being used for the treatment of colon cancer.
Accurate estimation of flow discharge in a compound river channel is increasingly important in river management and hydro-environment design.
First, it is increasingly recognized that while CO2, a compound exhaled by all mammals, induces mosquito activation, it does not provide accurate orientational cues to the anthropophilic An. gambiae [24], [42].
Haplotyping can enable the detection of compound heterozygosity, which is increasingly recognized as an important cause of genetic disease [ 64, 84 - 86 ].
This is increasingly enabled by the growing availability of potent compounds and kinome-wide binding data.
