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This number is increasing twofold every 20 years and will likely reach 115 million people by 2050 [ 3, 4].
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A recent meta-analysis (15,877 subjects, 17 studies, average follow-up of 7.7 years) has shown that the risk of cardiovascular events is increased twofold in patients with increased PWV [ 20].
Mortality is increased twofold in patients with AF.
When number of stored silhouettes is increased twofold, the surety level increases to 40%to80%0% and when the stored silhouettes are increased four times, the surety level increases to around 80%to100%0%.
Goddu et al. estimates that the radiation dose to the nucleus in a single cell is increased twofold if 111In is located in the cytoplasm compared to the cell surface and about 20-fold if located in the nucleus [43].
The purification yield of DAMP4var-pexiganan protein is increased twofold with a 72.9% of the protein recovery in this study as compared to the previous purification processes (Dwyer in Chem Eng Sci 105:12014, 2014).
The rate of fracture is increased twofold among persons with RA.
Furthermore, the risk of CV death is increased twofold to fourfold in people with T2D.
The risk for cardiovascular mortality among those with schizophrenia is increased twofold as compared with patients without schizophrenia [ 3].
Risk is increased twofold to threefold in those with insulin levels in the highest (versus lowest) quartile.
In vivo, FOXO1 DNA activity is increased twofold in diabetic wounds, and the increase is driven by diabetes-enhanced TNF levels [ 59].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com