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It is in weak moments like this that we make that fatal mistake, and turn to the internet.
This variability might by due to the "flip-flop" phenomenon, which occurs, in complex traits, when the associated allele is in weak linkage disequilibrium (LD) with the true causal variant.
A previous study (40) reported an association between migraines and another SNP in PRDM16, rs2651899, which is in weak LD with rs61759167 (r ≈ 0.44).
Using a combination of hydrodynamic techniques we now show that apo-NEMO is a highly elongated, dimeric protein that is in weak equilibrium with a tetrameric assembly.
It is interesting to note that rs12237222 is in weak but highly significant linkage disequilibrium with rs11139451 (D′ = 0.257, P = 1.45 × 10−6) that has been found to show the maximum HLOD score in the study of Allen-Brady et al. [ 20] (Supplementary Table 4).
The conditional information haplotype score used here was developed in part to address these technical issues, which are related to the initial observation made by biologists in our group - that a marker in a long haplotype might be only a few hundred bases away from a second marker with which the long haplotype is in weak linkage.
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The effect of the debt is that the U.S. is in weaker political position negotiating with allies and other countries.
Even those with jobs are in weak positions.
Paradoxically, he says, the best returns during times of inflation have often been in weak currencies like the Turkish lira.
The majority (98%) of SNP pairs ≤10 Mb apart are in weak LD (r2≤0.30; Figure S2).
The two SNPs are located on chromosome 6q23 and are in weak LD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com