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In this way we provide an index which is useful for quantifying how essential each gene is in the activation of the functional module.
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GBF1 is assumed to be involved in the activation of Adh1, which is a hypoxia-responsive protein.
It has been known that Bax is involved in the activation of caspases.
Therefore, it is unlikely that MT1-MMP/TIMP2/MMP2 complex is involved in the activation of pro-MMP9 in osteoclasts.
Similarly, D9 which is conserved across the GCG-like members is essential in the activation of mammalian GCGR [ 78].
Rheb, which is implicated in the activation of mTORC1, directly activates PLD1 [ 12].
It is reported to be involved in the activation of the HIV enhancer [ 27].
It was partly consistent with the previous report that TAK1 is involved in the activation of AMPK- α1.
Brain thromboxane A2 is involved in the activation of central adrenomedullary outflow and an active metabolite of arachidonic acid other than thromboxane A2 may be involved in activation of the central sympathetic outflow.
His74, therefore, has been proposed to be involved in the activation of ASIC2a by protons [7].
Both proteins are known to be involved in the activation of macrophages during inflammation [ 59, 60].
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