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Notably, this SNP is highly expressed in human Amerindian populations, up to 45% in the Paez, and is in linkage with Amerindian HLA haplotypes [19], suggesting that it is a marker for a cassette of genes that are positively selected in humans.
Finally, Medtr7g085120.1 is an apyrase-like protein and is in linkage with two genes (Medtr7g084910.1, Medtr7g084940.1) involved in flavonoid synthesis.
In addition, the TaqIA SNP is in linkage with a couple of non-synonymous SNPs of the ANKK1 gene [ 65].
One explanation may be that this genetic variant is in linkage with other SNPs that do influence the amino-acid sequence of ERCC5.
They reported a statistical significant association only for one SNP, rs4420638, that is located near APOC1 and is in linkage with APOE [ 26].
11, 19 Therefore, it is possible that this variant is a marker of other functional polymorphisms or is in linkage with currently unidentified causal variants affecting FA concentrations.
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The MHC microsatellites used here are known to be in linkage with MHC Class I, II, and III genes [67].
In the first stage, microsatellites were typed in the 17q11.2 region, previously independently found to be in linkage with MS. One significant association was found at microsatellite D17S798.
In addition, the nonMHC markers were highly polymorphic and therefore likely to be in linkage with functional loci under balancing selection [e.g. 68], [69].
Because the nonMHC loci were highly polymorphic, they are likely to be in linkage with nearby functional loci under balancing selection [68], [69].
Although we measured genetic diversity using microsatellites assumed to be selectively neutral, the MHC markers used here are known to be in linkage with MHC genes [67].
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