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As Cystatin E/M targets proteases in skin [ 35, 37], its suggested role is in differentiation and cornification of keratinocytes in hair follicles and nails [ 38, 39].
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The challenge will be in differentiation.
The size of an inversion can also determine how effective genetic exchange can be in differentiation among gene arrangements.
One area of clinical application is in the differentiation between abscess and primary tumour.
The myogenin promoter is active in differentiation conditions and its activity is regulated by MyoD.
There is increasing evidence that Notch signalling is involved in differentiation and activation of osteoclasts.
In cornea, of 113 genes expressed, 79 were upregulated and were involved in differentiation, including terminal differentiation (table 2).
MuSCs were differentiated in differentiation medium (DMEM (Invitrogen) with 2% horse serum (Sigma)).
It is implicated in differentiation, proliferation, cell-adhesion, and migration.
Recent studies also suggest that NADPH oxidase is involved in differentiation of stem cells.
This factor is involved in differentiation processes related to NOTCH signalling [83].
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