Ca2+ signaling is important for regulating sperm motility, most notably in this context for flagellar function and regulation (Marquez et al. 2006; Lindemann et al. 1987; Ignotz and Suarez 2005; Ho et al. 2002; Darszon et al. 2011).
The physical presence of another person's body is important for regulating the circadian rhythm, dopamine levels, the immune response, menstrual cycles, and much else.
Controlling the rate and extent of protein digestion within different regions of the human gastrointestinal tract (GIT) is important for regulating hormonal responses (such as hunger, satiety, and satiation) and immune responses (such as allergenicity).
NO homeostasis, based on the balance between NO synthesis and degradation, is important for regulating its physiological functions, since an excess of NO causes nitrosative stress due to the high reactivity of NO and NO-derived compounds.
Recent studies have confirmed the view that maintenance of proteolytic function is important for regulating energy metabolism: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (Pfkfb3), which generates fructose 2,6-bisphosphate, is subject to continuous proteasome-mediated degradation following its ubiquitination [56, 57].
Their balance is important for regulating gene expression.
Dissection of cis-elements reveals an intronic element, In100, which is important for regulating casp-2 alternative splicing.
If chromatin ubiquitination is important for regulating the balance between mutagenic and faithful DNA repair in Ig gene hypermutation, one might predict that AID could deaminate multiple genes but the resulting uracils are faithfully repaired at the non-Ig loci.
Cell culture analysis revealed that, PHD2 has a dominant role in controlling HIF-1α in normoxia [15], while PHD3 is important for regulating HIF in hypoxia or upon re-oxygenation [13].
We have previously shown that cross-talk between MAPK pathways and other signalling events is important for regulating andothelial COX-2 expression and prostanoid synthesis, as well as for functional responses in other cell types [27], [32].
In order to determine whether dephosphorylation of PTB is important for regulating its binding to fosB I4, His-tagged PTB 1 was expressed by transient transfection and isolated from HeLa cells.
