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Treating depression among patients with chronic kidney disease (CKD) is imperative because of its high prevalence and health-related costs.

In the case of the apicomplexan parasite Toxoplasma gondii, the need to find alternative treatments is imperative because of the poor tolerability and frequent side-effects associated with existing therapeutic strategies.

Understanding dynamics of both dissolved and particulate-bound nutrient dynamics during runoff events is imperative, because of their differing roles in terms of nutrient bioavailability and potential implications for plant dynamics.

Probing the interaction between the PVP molecules and Au NP is imperative because of possible medicinal, biosensing, bioconjugation, and catalytic applications.

Understanding lysogeny is imperative because of its impacts on host phenotype, community composition and perhaps most importantly, gene transfer processes [reviewed in [9]].

An accurate diagnosis is imperative because of its poor prognosis.

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Fairly allocating the burden of proof is imperative because, as Justice Robert Jackson once wrote, the overreliance on theories of conspiracy in criminal law can be "a serious threat to fairness in our administration of justice".

Early detection of precursor lesions is imperative because without treatment, all grades of CIN may progress to invasive cervical cancer, although CIN 1 lesions progress less frequently [ 4, 5].

Santos said rapid passage and implementation of the deal was imperative because of signs that a cease-fire in effect since July 2015 was breaking down.

We also learnt that institution-wide involvement was imperative because of the large number of patients at risk for VTE.

The rigorous analytical processes detailed in the online appendices (Supporting Information) were imperative because of the unique and critical problem in making inferences from all such studies.

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