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Investigations of the PK-PD relationship of a CNS drug should therefore be designed such that the contribution of a particular process is identified (for example by systematically influencing the process), and that information is obtained on time-dependency and on the unbound plasma and target tissue drug concentrations that drive the effect.
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A Muslim woman can be identified, for example, without touching her or asking her to drop her facial veil.
Recipients are identified, for example, using a combination of census data, satellite imagery and door-to-door visits looking for homes with thatched roofs – which the charity uses as an "objective indicator" of poverty.
A third group, 'other mechanism', had 70 cases (37.3 %) in which a more heterogeneous collection of mechanisms were identified, for example, sport-related, aggression or unknown.
Moreover, "hot" cargo categories were identified; for example, textile products accounted for 34%% (tax rate of 12%%) of tax evasion cases, 30%% for electronic products (tax rate of 7.5%%), and 8%% for mechanical products (tax rate of 6%%).
These schemes however increase the resource consumption while attacks targeting the reputation protocol itself have already been identified: for example, spreading wrong information or behaving differently towards different neighbors, the reputation exchange protocol can be deceived [20].
Ever since its discovery, multiple kinds of different AS types have been identified, for example, exon skipping (or cassette exon), intron retention, alternative 3′/5′ splice site (SS) and so on (Wang et al., 2008).
Several within-sex predictors of misperceptions were identified; for example, individuals high in self-perceived mate value reported more false-positive inferences by others than did individuals lower in mate value.
Tetrapeptides with Ki values in the high nanomolar range were identified, for example Suc-Chg-Glu-2-Nal-Cys (Ki=0.27±0.03 μM) and Suc-Dif-Glu-Glu-Cys (Ki=0.40±0.10 μM).
Several mutants with higher rates of activities and with different regiospecificities were identified; for example, Escherichia coli TG1 cells expressing either TouA mutant M180T/E284G or E214G/D312N/M399V produce 4-NC 4.5- and 20-fold faster than wild-type ToMO (0.037 and 0.16 nmol/min mg protein from p-NP, respectively).
Still, specific posttranslational modifying enzymes remain to be identified, for example the enzymes responsible for the acetylation of the secretory peptides β-endorphin and α-MSH.
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CEO of Professional Science Editing for Scientists @ prosciediting.com