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The purpose of an open chromatin state is hypothesized to create the plasticity for mounting a rapid response to differentiation signals (reviewed in 47).
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Neurons that are proximal to plaques display aberrant dystrophic neurites with disrupted trajectories indicative of synaptic dysfunction (for example, [ 88]) and plaques have been hypothesized to create and sustain neurotoxic microenvironments [ 89] and perturb mitochondrial function [ 90].
The persistent efforts for malaria elimination in Moheli can be hypothesized to create a Mayotte-like setting requiring efficient vector control to prevent epidemics in a Mohelian population that is losing its immunity.
Mitochondrial dysfunction is hypothesized to play a role in asthma.
Information is hypothesized to work in the same way on respondents preferring Romney.
The T-to-C substitution was initially hypothesized to create an Sp-1 binding site, which could lead to up-regulation of transcriptional activation of the variant allele and higher activity of the enzyme [ 8, 9], but this was not observed in experimental studies [ 10- 12].
This resurfacing modality has been hypothesized to function by forming a layer of desiccated epidermis creating a natural barrier that facilitates accelerated healing with generation of new epidermis.
In addition, overlapping genes were hypothesized to be a means of genome size reduction [11], as well as a mechanism for creating new genes [12].
This occurrence has been hypothesized to be the result of subclinical lesions being uncovered as opposed to new lesions being created.
Several mechanisms were hypothesized to trigger this phenomenon.
These are hypothesized to be groups in process of consolidation.
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